American Board of Surgery Qualifying Exam (ABS QE) Practice Test

Disable ads (and more) with a membership for a one time $2.99 payment

Prepare for the American Board of Surgery Qualifying Exam. Utilize interactive flashcards and multiple-choice questions, complete with hints and analysis. Ace your upcoming exam!

Each practice test/flash card set has 50 randomly selected questions from a bank of over 500. You'll get a new set of questions each time!

Practice this question and more.

What is the typical hormone receptor profile of Luminal A breast cancer?

ER - , PR + , Her2 +
ER + , PR + , Her2 -
ER + , PR - , Her2 +
ER - , PR - , Her2 -

The correct answer is: ER + , PR + , Her2 -

The typical hormone receptor profile of Luminal A breast cancer is characterized by the presence of estrogen receptors (ER positive) and progesterone receptors (PR positive), along with the absence of overexpression of the human epidermal growth factor receptor 2 (Her2 negative). This profile indicates a subtype of breast cancer that is generally associated with a more favorable prognosis and often responds well to hormonal therapies. Luminal A tumors are typically slower growing and have lower grades compared to other subtypes, which makes the understanding of their hormone receptor status crucial for management and treatment. In this case, the coexpression of ER and PR signifies that these tumors can be treated effectively with endocrine therapies, enhancing the overall survival rates of patients diagnosed with this subtype. In contrast to other subtypes, such as Luminal B, which may show variations like lower hormone receptor positivity or Her2 positivity, Luminal A cancers stand out due to their profile, making this information significant in guiding treatment decisions.